Fibronectin

Fibronectin
(Science: protein) glycoprotein of high molecular weight (2 chains each of 250 kd linked by disulphide bonds) that occurs in insoluble fibrillar form in extracellular matrix of animal tissues and soluble in plasma, the latter previously known as cold insoluble globulin. The various slightly different forms of fibronectin appear to be generated by tissue specific differential splicing of fibronectin mrna, transcribed from a single gene. Fibronectins have multiple domains that confer the ability to interact with many extracellular substances such as collagen, fibrin and heparin and also with specific membrane receptors on responsive cells. Notable is the RGD domain recognised by integrins and two repeats of the egf like domain. Interaction of a cells fibronectin receptors (members of the integrin family) with fibronectin adsorbed to a surface results in adhesion and spreading of the cell.

Control of Growth & Development tutorials look at how the genetic makeup determines the biological processes on a da..

This tutorial deals with the abiotic factors of the freshwater environment that determine what sort of life would be sui..

Find out more about New Zealand's unique biodiversity by exploring a range of different ecosystems and the key role of s..

The endoplasmic reticulum and Golgi apparatus are the organelles involved in the translation step of protein synthesis a..

Stems primarily provide plants structural support. This tutorial includes lectures on the external form of a woody twig ..

Lentic or still water communities can vary greatly in appearance -- from a small temporary puddle to a large lake. The s..

You will also like...