Dictionary > Megakaryocyte

Megakaryocyte

Definition
noun, plural: megakaryocytes
A large cell in the bone marrow with characteristic lobulate nucleus and is primarily involved in the production of blood thrombocytes or platelets
Supplement
Hematopoiesis is the process of forming new blood cellular elements in vertebrates. In this regard, thrombopoiesis is a hematopoiesis leading to the formation of thrombocytes. It begins with a multipotent stem cell, a hemocytoblast, which gives rise to a common myeloid progenitor cell. The progenitor cell, in turn gives rise to colony forming unit (particularly, CFU-Me, which is also referred to as CFU-Meg or CFU-Mega) fated to become megakaryocytes. The CFU-Me gives rise to megakaryoblasts. A megakaryoblast is the precursor for a promegakaryocyte. The promegakaryocyte, in turn, is the precursor cell for a megakaryocyte. The process in which the promegakaryocyte differentiates into a mature megakaryocyte is called megakaryopoiesis. Thrombopoietin is the hormone that stimulates megakaryopoiesis. The hormone is produced by the liver and the kidney, and encoded by the THPO gene.
Megakaryocytes are the mature form of promegakaryocytes. These cells owe their name from their large cell size that is 10 times larger than a typical erythrocyte. It is large because within the cell the DNA replicates but does not involve cytokinesis, a process referred to as endoreduplication. Thus, the cell appears to contain many nuclei but it only has a single nucleus that became large and lobulated. The demarcation membrane system forms to demarcate platelets, which soon break off from the megakaryocyte and move to the peripheral blood.
A metamegakaryocyte is a form of megakaryocyte with aggregated granules in the cytoplasm. Granular platelets begin to form at the periphery of the cytoplasm of a metamegakaryocyte.
Word origin: Greek mégas (“large”) + Greek karuo– (“nut”) + –cyte (cell)
Variant(s):

  • megacaryocyte

Synonym(s):

  • megalokaryocyte
  • See also:

    Related form(s):

  • megakaryocytic (adjective, of, relating to, or pertaining to a megakaryocyte)


  • You will also like...

    Plant meristem
    Plant Meristems and Growth

    In plants, growth occurs in meristems, which are the site of repeated cell division of unspecialized cells. These cells ..

    The Human Physiology
    The Human Physiology

    Physiology is the study of how living organisms function. Thus, human physiology deals specifically with the physiologic..

    DNA molecule
    Genetic Control – On and Off Genes

    Genes are the blueprint of our bodies, a blueprint that creates a variety of proteins essential to any organism's surviv..

    Geological Periods
    Geological Periods

    Geological periods is a study guide that cites the different geological periods on Earth's timeline. Each has a brief ov..

    Chromosomes X and Y and Sex Determination
    Chromosomes X and Y and Sex Determination

    This tutorial looks at sex determination via the sex chromosomes, X and Y. Read it to get more info on X and Y chromosom..

    Structural depiction of catalase, an enzyme
    Protein Activity and Cellular Metabolism

    Proteins have a crucial role in various biological activities. Get to know how proteins are able to perform as enzymes, ..

    Related Articles...

    No related articles found

    See all Related Topics